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1

Homozygotes for oculopharyngeal muscular dystrophy have a severe form of the disease

Sergiu C. Blumen, Bernard Brais, Amos D. Korczyn, Susan Medinsky, Joab Chapman, Alexander Asherov, Puiu Nisipeanu, François Codère, Jean-Pierre Bouchard, Michel Fardeau, Fernando M. S. Tomé, Guy A. Ro

Journal:

Annals of Neurology

Année:

1999

Langue:

english

Fichier:

PDF, 1.22 MB

english, 1999

2

Effect of four-week repeated inhalation exposure to unconjugated azodicarbonamide on specific and non-specific airway sensitivity of the guinea pig

Robert F. Gerlach, Michele A. Medinsky, Charles H. Hobbs, David E. Bice, William E. Bechtold, Yung-Sung Cheng, Nancy A. Gillett, Linda S. Birnbaum, Joe L. Mauderly

Journal:

Journal of Applied Toxicology

Année:

1989

Langue:

english

Fichier:

PDF, 962 KB

english, 1989

3

Measurement of steady-state blood concentrations in B6C3F1 mice exposed by inhalation to vinylidene fluoride

Michele A. Medinsky, William E. Bechtold, Linda S. Birnbaum, Rogene F. Henderson

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 438 KB

english, 1990

4

Metabolism of butadiene by mice, rats, and humans: a comparison of physiologically based toxicokinetic model predictions and experimental data

James A. Bond, Matthew W. Himmelstein, Mark Seaton, Pieter Boogaard, Michele A. Medinsky

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 652 KB

english, 1996

5

Physiologically based pharmacokinetic modeling of blood and tissue epoxide measurements for butadiene

Lisa M. Sweeney, Matthew W. Himmelstein, Paul M. Schlosser, Michele A. Medinsky

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 330 KB

english, 1996

6

Sites and mechanisms for uptake of gases and vapors in the respiratory tract

Michele A. Medinsky, James A. Bond

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 171 KB

english, 2001

7

The use of toxicologic data in mechanistic risk assessment: 1,3-butadiene as a case study

James A. Bond, Matthew W. Himmelstein, Michele A. Medinsky

Journal:

International Archives of Occupational and Environmental Health

Année:

1996

Langue:

english

Fichier:

PDF, 628 KB

english, 1996

8

Benzene: a case study in parent chemical and metabolite interactions

Michele A. Medinsky, Elaina M. Kenyon, Paul M. Schlosser

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 894 KB

english, 1995

9

Differences in Rates of Benzene Metabolism Correlate with Observed Genotoxicity

Elaina M. Kenyon, Robert E. Kraichely, Kinnya T. Hudson, Michele A. Medinsky

Journal:

Toxicology and Applied Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 121 KB

english, 1996

10

Reduction of Benzene Metabolism and Toxicity in Mice That Lack CYP2E1 Expression

John L. Valentine, Susanna S.-T. Lee, Mark J. Seaton, Bahman Asgharian, Georgia Farris, J.Christopher Corton, Frank J. Gonzalez, Michele A. Medinsky

Journal:

Toxicology and Applied Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 192 KB

english, 1996

11

A Comparison of Physiologically Based Pharmacokinetic Model Predictions and Experimental Data for Inhaled Ethanol in Male and Female B6C3F1Mice, F344 Rats, and Humans

Gina M. Pastino, Bahman Asgharian, Kay Roberts, Michele A. Medinsky, James A. Bond

Journal:

Toxicology and Applied Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 162 KB

english, 1997

12

To the Editor

Michele A. Medinsky, James A. Bond

Journal:

Toxicology and Applied Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 14 KB

english, 1998

13

Biliary excretion and enterohepatic circulation of 2,4-dinitrotoluene metabolites in Fischer-344 rats

Michele A. Medinsky, John G. Dent

Journal:

Toxicology and Applied Pharmacology

Année:

1983

Langue:

english

Fichier:

PDF, 605 KB

english, 1983

14

Absorption, distribution, and retention of inhaled selenious acid and selenium metal aerosols in Beagle dogs

Suzanne H. Weissman, Richard G. Cuddihy, Michele A. Medinsky

Journal:

Toxicology and Applied Pharmacology

Année:

1983

Langue:

english

Fichier:

PDF, 498 KB

english, 1983

15

Metabolism of 1-[14C]nitropyrene in isolated perfused rat livers

James A. Bond, Michele A. Medinsky, John S. Dutcher

Journal:

Toxicology and Applied Pharmacology

Année:

1984

Langue:

english

Fichier:

PDF, 677 KB

english, 1984

16

Disposition and metabolism of 2,3-[14C]dichloropropene in rats after inhalation

James A. Bond, Michele A. Medinsky, John S. Dutcher, Rogene F. Henderson, Yung Sun Cheng, James A. Mewhinney, Linda S. Birnbaum

Journal:

Toxicology and Applied Pharmacology

Année:

1985

Langue:

english

Fichier:

PDF, 765 KB

english, 1985

17

Disposition of [14C]methyl bromide in rats after inhalation

James A. Bond, John S. Dutcher, Michele A. Medinsky, Rogene F. Henderson, Linda S. Birnbaum

Journal:

Toxicology and Applied Pharmacology

Année:

1985

Langue:

english

Fichier:

PDF, 824 KB

english, 1985

18

Deposition, metabolism, and excretion of 1-[14C]nitropyrene and 1-[14C]nitropyrene coated on diesel exhaust particles as influenced by exposure concentration

James A. Bond, James D. Sun, Michele A. Medinsky, Robert K. Jones, Hsu C. Yeh

Journal:

Toxicology and Applied Pharmacology

Année:

1986

Langue:

english

Fichier:

PDF, 1.31 MB

english, 1986

19

The effect of molecular weight/lipophilicity on clearance of organic compounds from lungs

Rogene F. Henderson, William E. Bechtold, Michele A. Medinsky, Joanna P.-Fischer, Tyrone T. Lee

Journal:

Toxicology and Applied Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 567 KB

english, 1988

20

Disposition of inhaled 1-chloro-2-propanol in F344N rats

James A. Bond, Linda S. Birnbaum, Alan R. Dahl, Michele A. Medinsky, Patrick J. Sabourin, Rogene F. Henderson

Journal:

Toxicology and Applied Pharmacology

Année:

1988

Langue:

english

Fichier:

PDF, 962 KB

english, 1988

21

Disposition of inhaled isoprene in B6C3F1 mice

James A. Bond, William E. Bechtold, Linda S. Birnbaum, Alan R. Dahl, Michele A. Medinsky, James D. Sun, Rogene F. Henderson

Journal:

Toxicology and Applied Pharmacology

Année:

1991

Langue:

english

Fichier:

PDF, 908 KB

english, 1991

22

Effect of exposure concentration on the disposition of inhaled butoxyethanol by F344 rats

Patrick J. Sabourin, Michele A. Medinsky, Linda S. Birnbaum, William C. Griffith, Rogene F. Henderson

Journal:

Toxicology and Applied Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 860 KB

english, 1992

23

Insights into the toxicokinetics and toxicodynamics of 1,3-butadiene

James A Bond, Michele A Medinsky

Journal:

Chemico-Biological Interactions

Année:

2001

Langue:

english

Fichier:

PDF, 298 KB

english, 2001

24

Disposition of butadiene epoxides in Sprague-Dawley rats

John L Valentine, Pieter J Boogaard, Lisa M Sweeney, Max J Turner, James A Bond, Michele A. Medinsky

Journal:

Chemico-Biological Interactions

Année:

1997

Langue:

english

Fichier:

PDF, 304 KB

english, 1997

25

Acute methanol toxicity in minipigs

David C. Dorman, Janice A. Dye, Mark P. Nassise, Jethro Ekuta, Brad Bolon, Michele A. Medinsky

Journal:

Fundamental and Applied Toxicology

Année:

1993

Langue:

english

Fichier:

PDF, 2.83 MB

english, 1993

26

Advances in biologically based models for respiratory tract uptake of inhaled volatiles

Michele A. Medinsky, Julia S. Kimbell, John B. Morris, Per Gerde, John H. Overton

Journal:

Fundamental and Applied Toxicology

Année:

1993

Langue:

english

Fichier:

PDF, 1.39 MB

english, 1993

27

Biliary excretion and enterohepatic circulation of 1-nitropyrene metabolites in fischer-344 rats

Michele A. Medinsky, Heather Shelton, James A. Shelton, Roger O. McClellan

Journal:

Biochemical Pharmacology

Année:

1985

Langue:

english

Fichier:

PDF, 581 KB

english, 1985

28

The application of physiologically based pharmacokinetic/ pharmacodynamic (PBPK/PD) modeling to understanding the mechanism of action of hazardous stances

Michele A. Medinsky

Journal:

Toxicology Letters

Année:

1995

Langue:

english

Fichier:

PDF, 725 KB

english, 1995

29

Recent developments in methanol toxicity

Michele A. Medinsky, David C. Dorman

Journal:

Toxicology Letters

Année:

1995

Langue:

english

Fichier:

PDF, 452 KB

english, 1995

30

Health risk assessment of chemical mixtures from a research perspective

James A. Bond, Michele A. Medinsky

Journal:

Toxicology Letters

Année:

1995

Langue:

english

Fichier:

PDF, 472 KB

english, 1995

31

Pharmacokinetic Modeling Approaches for Describing the Uptake, Systemic Distribution, and Disposition of Inhaled Chemicals

Gargas, Michael L., Medinsky, Michele A., Andersen, Melvin E.

Journal:

Critical Reviews in Toxicology

Année:

1995

Langue:

english

Fichier:

PDF, 1.32 MB

english, 1995

32

A COMPREHENSIVE EVALUATION OF THE POTENTIAL HEALTH RISKS ASSOCIATED WITH OCCUPATIONAL AND ENVIRONMENTAL EXPOSURE TO STYRENE

Cohen, Joshua T., Carlson, Gary, Charnley, Gail, Coggon, David, Delzell, Elizabeth, Graham, John D., Greim, Helmut, Krewski, Daniel, Medinsky, Michele, Monson, Richard, Paustenbach, Dennis, Petersen,

Journal:

Journal of Toxicology and Environmental Health Part B

Année:

2002

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2002

33

In vivo metabolism of butadiene by mice and rats: a comparison of physiological model predictions and experimental data

Medinsky, Michele A., Leavens, Teresa L., Csanády, György A., Gargas, Michael L., Bond, James A.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 1.24 MB

english, 1994

34

Age-related changes in benzene disposition in male C57BL/6N mice described by a physiologically based pharmacokinetic model

McMahon, Timothy F., Medinsky, Michele A., Birnbaum, Linda S.

Journal:

Toxicology Letters

Année:

1994

Langue:

english

Fichier:

PDF, 940 KB

english, 1994

35

The Effect of Dose, Dose Rate, Route of Administration, and Species on Tissue and Blood Levels of Benzene Metabolites

Rogene F. Henderson, Patrick J. Sabourin, William E. Bechtold, William C. Griffith, Michele A. Medinsky, Linda S. Birnbaum and George W. Lucier

Journal:

Environmental Health Perspectives

Année:

1989

Langue:

english

Fichier:

PDF, 1.80 MB

english, 1989

36

Differences in the Pathways for Metabolism of Benzene in Rats and Mice Simulated by a Physiological Model

Michele A. Medinsky, Patrick J. Sabourin, Rogene F. Henderson, George Lucier and Linda S. Birnbaum

Journal:

Environmental Health Perspectives

Année:

1989

Langue:

english

Fichier:

PDF, 1.53 MB

english, 1989

37

Supplement 2: Chemical Sensitivity || Neurogenic Inflammation: With Additional Discussion of Central and Perceptual Integration of Nonneurogenic Inflammation

Rebecca Bascom, William J. Meggs, Mark Frampton, Kenneth Hudnell, Kaye Killburn, Gerd Kobal, Michelle Medinsky and William Rea

Journal:

Environmental Health Perspectives

Année:

1997

Langue:

english

Fichier:

PDF, 365 KB

english, 1997

38

Supplement 6: Benzene Toxicity, Carcinogenesis, and Epidemiology || Mechanistic Considerations in Benzene Physiological Model Development

Michele A. Medinsky, Elaina M. Kenyon, Mark J. Seaton and Paul M. Schlosser

Journal:

Environmental Health Perspectives

Année:

1996

Langue:

english

Fichier:

PDF, 361 KB

english, 1996

39

Supplement 9: Toxicological Evaluation of Chemical Interactions || 1,3-Butadiene: Linking Metabolism, Dosimetry, and Mutation Induction

James A. Bond, Gyuri A. Csanady, Michael L. Gargas, F. Peter Guengerich, Teresa Leavens, Michele A. Medinsky and Leslie Recio

Journal:

Environmental Health Perspectives

Année:

1994

Langue:

english

Fichier:

PDF, 1.84 MB

english, 1994

40

Supplement 9: Toxicological Evaluation of Chemical Interactions || Critical Issues in Benzene Toxicity and Metabolism: The Effect of Interactions with Other Organic Chemicals on Risk Assessment

Michele A. Medinsky, Paul M. Schlosser and James A. Bond

Journal:

Environmental Health Perspectives

Année:

1994

Langue:

english

Fichier:

PDF, 1.15 MB

english, 1994

41

Disposition and Metabolism of [ 14 C]Dibenzo[c,g]carbazole Aerosols in Rats after Inhalation

BOND, JAMES A., AYRES, PAUL H., MEDINSKY, MICHELE A., CHENG, YUNG-SUNG, HIRSHFIELD, DAVID, McCLELLAN, ROGER O.

Journal:

Toxicological Sciences

Année:

1986

Langue:

english

Fichier:

PDF, 675 KB

english, 1986

42

Benzene Hemoglobin Adducts in Mice and Rats: Characterization of Formation and Physiological Modeling

SUN, JAMES D., MEDINSKY, MICHELE A., BIRNBAUM, LINDA S., LUCIER, GEORGE, HENDERSON, ROGENE F.

Journal:

Toxicological Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 512 KB

english, 1990

43

Dose‐, route‐, and sex‐dependent urinary excretion of phenol metabolites in B6C3F 1 mice

Kenyon, Elaina M., Seeley, Maureen E., Janszen, Derek, Medinsky, Michele A.

Journal:

Journal of Toxicology and Environmental Health

Année:

1995

Langue:

english

Fichier:

PDF, 895 KB

english, 1995

44

Benzene and phenol metabolism by mouse and rat liver microsomes

Schlosser, Paul M., Bond, James A., Medinsky, Michele A.

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 2.86 MB

english, 1993

45

Benzene metabolism by human liver microsomes in relation to cytochrome P450 2E1 activity

Seaton, Mark J., Schlosser, Paul M., Bond, James A., Medinsky, Michele A.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 804 KB

english, 1994

46

Advances in Biologically Based Models for Respiratory Tract Uptake of Inhaled Volatiles

MEDINSKY, MICHELE A., KIMBELL, JULIA S., MORRIS, JOHN B., GERDE, PER, OVERTON, JOHN H.

Journal:

Toxicological Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 2.04 MB

english, 1993

47

Dog pulmonary macrophage metabolism of free and particle‐associated [ 14 C]benzo[a]pyrene

Bond, James A., Butler, Michelle M., Medinsky, Michele A., Muggenburg, Bruce A., McClellan, Roger O.

Journal:

Journal of Toxicology and Environmental Health

Année:

1984

Langue:

english

Fichier:

PDF, 491 KB

english, 1984

48

Acute Methanol Toxicity in Minipigs

DORMAN, DAVID C., DYE, JANICE A., NASSISE, MARK. P., EKUTA, JETHRO, BOLON, BRAD, MEDINSKY, MICHELE A.

Journal:

Toxicological Sciences

Année:

1993

Langue:

english

Fichier:

PDF, 1.56 MB

english, 1993

49

Uptake of Vinylidene Fluoride in Rats Simulated by a Physiological Model

MEDINSKY, MICHELE A., BECHTOLD, WILLIAM E., BIRNBAUM, LINDA S., CHICO, DAVID M., GERLACH, ROBERT F., HENDERSON, ROGENE F.

Journal:

Toxicological Sciences

Année:

1988

Langue:

english

Fichier:

PDF, 678 KB

english, 1988

50

In vitro conjugation of benzene metabolites by human liver: potential influence of interindividual variability on benzene toxicity

Seaton, Mark J., Schlosser, Paul M., Medinsky, Michele A.

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 892 KB

english, 1995